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LONGEVITY / What we know about extending healthspan

A clinical-trial style tour of the hallmarks of aging, the interventions actually being tested in humans, and the honest limits of what biology will allow.

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A clinical-trial style tour of the hallmarks of aging, the interventions actually being tested in humans, and the honest limits of what biology will allow. Key sections include: LONGEVITY / What we know about extending healthspan; From 30 to 80 in a century — and almost none of it from anti-aging.; Lifespan vs healthspan . The goal isn't more years. It's more good years.; The Hallmarks of Aging López-Otín et al., 2013 · updated 2023; Caloric restriction moderate evidence; mTOR & rapamycin moderate evidence; Senolytics early human; Yamanaka factors preclinical Resetting the epigenetic clock; Metformin — the boring candidate moderate evidence; Exercise strongest evidence The intervention with no equal in 2026..

Key sections

  • 01LONGEVITY / What we know about extending healthspan
  • 02From 30 to 80 in a century — and almost none of it from anti-aging.
  • 03Lifespan vs healthspan . The goal isn't more years. It's more good years.
  • 04The Hallmarks of Aging López-Otín et al., 2013 · updated 2023
  • 05Caloric restriction moderate evidence
  • 06mTOR & rapamycin moderate evidence
  • 07Senolytics early human
  • 08Yamanaka factors preclinical Resetting the epigenetic clock

Topics covered

catalogfuturelongevity
Slide outline
  1. 01LONGEVITY / What we know about extending healthspan
  2. 02From 30 to 80 in a century — and almost none of it from anti-aging.
  3. 03Lifespan vs healthspan . The goal isn't more years. It's more good years.
  4. 04The Hallmarks of Aging López-Otín et al., 2013 · updated 2023
  5. 05Caloric restriction moderate evidence
  6. 06mTOR & rapamycin moderate evidence
  7. 07Senolytics early human
  8. 08Yamanaka factors preclinical Resetting the epigenetic clock
  9. 09Metformin — the boring candidate moderate evidence
  10. 10Exercise strongest evidence The intervention with no equal in 2026.
  11. 11Sleep, diet, stress Foundational. Multipliers on everything else.
  12. 12What's actually decades away. What's available today.
  13. 13Where to go next.
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Updated
2026-05-17
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